The sale of Romelu Lukaku leaves Manchester United weak up front and Sunday's visitors can take full advantage under their new manager.
Chelsea's transfer ban has meant that Frank Lampard has been unable to strengthen the Blues' squad this summer, but that has meant a bigger role for the club's cast of talented youngsters, while Christian Pulisic, who is effectively a new signing, has already made a strong impact in Chelsea's pre-season fixtures.
Although some pundits, including Dimitar Berbatov, are taking a positive view of United's chances this season, it will be tough for Ole Gunnar Solskjaer to steer this squad into the top four and I think Chelsea will underline that prospect on Sunday.
There are few rivalries as intense or as evenly-matched in Rugby Union as that between England and Wales. The head-to-head record, which began in 1881, stands 62 to 58 in England's favour, but Wales prevailed in their last meeting, a 21-13 victory at the Millennium Stadium to clinch the 2019 Grand Slam.
This is the first of two Rugby World Cup warm-up games so the focus for both teams will be on preparation but England coach Eddie Jones has been open about using these games to build a team, while Wales have opted for a more experienced line-up, led by Alun Wyn Jones who could set a new Test appearance record.
Home advantage will obviously be a boost to England, but at these odds, Wales look a little undervalued and they are worth backing to win this one.
There is plenty of top-class Rugby League action this weekend, but the pick of the NRL fixtures is this clash between second and third.
The Raiders go into this game in third place, having won their last four, including a 34-point win over the Warriors in their last outing. But they will be up against a Roosters line-up that warmed up for this game with 52-point thrashing of the Titans.
There's a good chance these two teams will meet again in the Finals, so this will be a fascinating game, but the Roosters, who boast the tournament's leading point scorer in Latrell Mitchell and the superb half-back pairing of Cooper Cronk and Luke Keary may just have the edge.
Total Odds for this multiple: 12/1. Remember, multiple prices are based on our Sportsbook product, so any winnings are exempt from commission.